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CD90 Rat anti-Mouse, Unlabeled, Clone: G7, BD

Catalog No. BDB553016 Shop All BD Biosciences Products
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BDB553016 0.5 mg
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Catalog No. BDB553016 Supplier BD Biosciences Supplier No. 553016
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Description

Rat Monoclonal Antibody

The G7 antibody reacts with the Thy-1.1 and Thy-1.2 alloantigens (CD90.1 and CD90.2, respectively) on thymocytes, peripheral T lymphocytes, some intraepithelial T lymphocytes (IEL, DEC), and neurons, but not B lymphocytes, of all mouse strains. CD90 is a GPI-anchored membrane glycoprotein of the Ig superfamily which is involved in signal transduction. In addition, there is evidence that CD90 mediates adhesion of thymocytes to thymic stroma. Soluble G7 mAb stimulates murine T-cell proliferation and IL-2 secretion, via signalling through the TCR/CD3 complex. mAb G7 has been reported to promote apoptosis of thymocytes and CTL clones, as determined by morphological and biochemical criteria. The Thy-1-triggered thymocyte death was found to be developmentally regulated and targeted mainly within the CD4+CD8+CD3- and CD4+CD8+CD3lo cultured immature thymocytes. G7 antibody does not react with Thy-1 (CD90) on rat thymocytes.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD90
Applications Flow Cytometry
Classification Monoclonal
Clone G7
Concentration 0.5mg/mL
Conjugate Unconjugated
Description Thy-1
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse T-cell hybridoma C 6/68
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2c κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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