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CD91 Mouse anti-Human, Unlabeled, Clone: A2MR-A2, BD

Catalog No. BDB550495 Shop All BD Biosciences Products
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Catalog No. BDB550495 Supplier BD Biosciences Supplier No. 550495
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Description

Mouse Monoclonal Antibody

Reacts with a 600kDa, type I membrane single protein, also known as the α2 Macroglobulin (α2M) receptor/low density lipoprotein (LDL) receptor. The single chain receptor undergoes cleavage, shortly after synthesis, into the 85kDa transmembrane β chain that non-covalently binds to the extracellular 500-515kDa a chain. It has a broad cellular distribution, but in the hematopoietic system it is expressed on monocyte lineage cells. The α2M/LDL receptor mediates endocytosis of a variety of ligands including α2M-proteinase complexes, plasminogen activators in complex with plasminogen activator inhibitor, Pseudomonas Exotoxin A. Ligand binding to α2M/LDL receptor is followed by rapid transport of the ligand to lysosomes for degradation.

Host Species: Mouse
Clone: A2MR-α2
Isotype: IgG1 κ
Species Reactivity: Human

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD91
Applications Flow Cytometry
Classification Monoclonal
Clone A2MR-A2
Concentration 0.5mg/mL
Conjugate Unconjugated
Description Alpha-2-macroglobulin receptor; α2MR; LRP-1; LDL Receptor-Related Protein-1
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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