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CD95 Mouse anti-Human, Unlabeled, Clone: G254-274, BD

Catalog No. BDB556370 Shop All BD Biosciences Products
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BDB556370 0.1 mg
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Catalog No. BDB556370 Supplier BD Biosciences Supplier No. 556370
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Description

Mouse Monoclonal Antibody

Programmed cell death (apoptosis) may be induced in response to a variety of cytotoxic stimuli, including activation of surface receptors. An area of particular interest has been the induction of apoptosis by the receptor-ligand pair: Fas (CD95) and Fas Ligand (FasL). Fas is an ∽45kDa cell surface protein which belongs to the the TNF (tumor necrosis factor receptor family, and is expressed in various tissue and cells including the thymus, liver, ovary and lung. FasL, a member of the TNF ligand family, is expressed on activated T and NK cells. FasL initiates signaling at the cell surface by aggregation of individual Fas recpetors via binding to the multivalent ligand. Antibodies which selectively activate Fas can be used in vitro to mimic the apoptotic response associated with FasL. Both Fas and FasL are thought to play an important role in the apoptotic processes that take place during T cell development. Clone G254-274 recognizes human Fas. A soluble form of recombinant human Fas (lacking the Fas transmembrane domain) was used as immunogen.

Host Species: Mouse
Clone: G254-274
Isotype: IgG1
Species Reactivity: Human
Immunogen: Recombinant Human Fas

Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD95
Applications Western Blot
Classification Monoclonal
Clone G254-274
Concentration 0.5mg/mL
Conjugate Unconjugated
Description Fas/APO-1
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Recombinant Human Fas
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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