CDw93 (C1qRp) Mouse anti-Human, Unlabeled, Clone: R3, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 551454

Catalog No. BDB551454

Description

The immunogen used to raise R3 was C1q-binding protein preparation as described. Human C1qRp is a 631 a.a. protein (∽66.5kD) protein that is highly expressed on monocytes/macrophages, neutrophil granulocytes but not on T and B lymphocytes. C1qRp binds C1q, the recognition subunit of the first component (C1) of the complement pathway, as well as MBL (Mannose-binding-lectin) and SPA (Pulmonary Surfactant Protein A). Human C1qRp is involved in the C1q-mediated enhancement of phagocytosis. R3 is suitable to detect C1qRp
expression on cells of myeloid lineage by flow cytometry, C1qRp in cellular lysates by Western blotting or immunoprecipitation. Pretreatment of monocytes with R3 neutralizes C1q-mediated enhancement of phagocytosis. In addition, when immobilized, R3 mimics C1q- MBL- or SPA-mediated enhancement of phagocytosis as reported. CDw93 (C1qRp) has been reported to define a human stem cell population with hematopoietic and hepatic potential.

Host Species: Mouse
Clone: R3
Isotype: IgM, κ
Species Reactivity: Human
Immunogen: C1q-binding protein

Flow Cytometry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: CDw93 (C1qRp)
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: C1qRp
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: R3
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: C1q-binding protein
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgM κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.