CDw93 Mouse anti-Human, FITC, Clone: R139, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 551531

Catalog No. BDB551531

Description

The immunogen used to raise R139 was a CDw93 preparation as described. CDw93 is also known as C1q-binding protein. Human C1qRp is a 631 amino acid protein (∽66.5kD) protein that is highly expressed on monocytes/macrophages, neutrophil granulocytes but not on T and B lymphocytes. C1qRp binds C1q, the recognition subunit of the first component (C1) of the complement pathway, as well as MBL (Mannose-binding-lectin) and SPA(Pulmonary Surfactant Protein A). Human C1qRp is involved in the C1q-mediated enhancement of phagocytosis. R139 is suitable to detect C1qRp expression on cells of myeloid lineage by flow cytometry, C1qRp in cellular lysates by Western blotting or immunoprecipitation. In addition, R139 neutralizes C1qmediated enhancement of phagocytosis, as reported. CDw93 (C1qRp) has been reported to define a human stem cell population with hematopoietic and hepatic potential.

Host Species: Mouse
Clone: R139
Isotype: IgG2b κ
Species Reactivity: Human

Flow Cytometry

Specifications

• Antigen: CDw93
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: Complement component C1q receptor; C1qRp; MXRA4
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: R139
• Conjugate: FITC
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Clq-CLF-binding proteins
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgG2b κ

For Research Use Only.