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Description
The M39-711 monoclonal antibody reacts with caudal-type homeobox transcription factor 2 (CDX-2). In embryonic development, CDX-2 is first expressed in the outer layer of the morula and later in the trophoblast, but not in embryonic stem cells. Along with Oct3/4, it is involved in the segregation of the trophoectoderm lineage from the inner cell mass. In the adult, CDX-2 expression is limited to the mucosa of the small and large intestines, where it regulates the synthesis of several intestine-specific proteins. Loss of CDX-2 expression is observed in some colorectal carcinomas, while gain of CDX-2 expression has been observed in gastric tumors and acute myeloid leukemias.
Host Species: Mouse
Clone: M39-711
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human CDX-2 Recombinant Protein
Bioimaging, Western Blotting
Specifications
Specifications
| Antigen | CDX-2 |
| Applications | Western Blot |
| Classification | Monoclonal |
| Clone | M39-711 |
| Concentration | 0.5mg/mL |
| Conjugate | Unconjugated |
| Description | CDX2, CDX3, CDX-3 |
| Formulation | Aqueous buffered solution containing ≤0.09% sodium azide. |
| Host Species | Mouse |
| Immunogen | Human CDX-2 Recombinant Protein |
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