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CENPO Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520826

Catalog No. PIPA520826


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Description

Description

A suggested positive control is mouse kidney tissue lysate. PA5-20826 can be used with blocking peptide PEP-0940.

Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.
Specifications

Specifications

CENPO
Polyclonal
Unconjugated
CENPO
Liquid
CENPO
A 16 amino acid peptide from near the center of human CENPO.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9BU64, Q8K015
CENP-O, ICEN-36, MCM21R; centromeric protein O; interphase centromere complex protein 36
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
52504, 684439, 79172
Documents
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