CENPO Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520826
A suggested positive control is mouse kidney tissue lysate. PA5-20826 can be used with blocking peptide PEP-0940.Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.
|A 16 amino acid peptide from near the center of human CENPO.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|CENP-O, ICEN-36, MCM21R; centromeric protein O; interphase centromere complex protein 36|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|52504, 684439, 79172|
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