Invitrogen™ CENPO Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520826

Catalog No. PIPA520826

Description

A suggested positive control is mouse kidney tissue lysate. PA5-20826 can be used with blocking peptide PEP-0940.

Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.

Specifications

• Antigen: CENPO
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CENPO
• Gene Alias: 2810429O05Rik; 8430427C03Rik; CENPO; CENP-O; Centromere protein O; centromeric protein O; D12Ertd482e; ICEN36; ICEN-36; Interphase centromere complex protein 36; MCM21R
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 52504, 684439, 79172
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8K015, Q9BU64
• Gene Symbols: CENPO
• Immunogen: A 16 amino acid peptide from near the center of human CENPO.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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