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Ceruloplasmin Mouse, Unlabeled, Clone: 8, BD

Catalog No. BDB611489 Shop All BD Biosciences Products
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BDB611489 150 μg
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Catalog No. BDB611489 Supplier BD Biosciences Supplier No. 611489

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Description

Mouse Monoclonal Antibody

Ceruloplasmin (CP) is a copper-containing glycoprotein that carries approximately 90% of plasma copper. CP contains six copper atom binding sites and is prone to transfer its copper atoms to tissues, however it is not essential for copper transport. In cultured endothelial cells, CP release of copper in the cytosol inhibits nitric oxide synthase activation, and this may be important for regulating vascular tone in blood vessels. In addition to its copper binding role, CP has also been shown to have ferroxidase activity, which involves conversion of ferrous to
ferric iron. The iron metabolism disorder aceruloplasminemia results from mutations in CP and is characterized by massive iron deposits in liver, pancreas, brain, retina, and other tissues. CP is expressed in the liver, the splenic reticuloendothelial system, the bronchiolar epithelium of the lung, and the retina and brain. The cell-specific expression of CP in neural tissues may account for the neuropathologies associated with aceruloplaminemia, while the wide expression pattern of CP may demonstrate its importance in the regulation of copper and iron levels in many tissues.

Host Species: Mouse
Clone: 8
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse ceruloplasmin aa. 233-355
Formula Weight [Chemical]: 132kDa

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Ceruloplasmin
Applications Western Blot
Classification Monoclonal
Clone 8
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse ceruloplasmin aa. 233-355
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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