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CHD3 Mouse, Unlabeled, Clone: 44, BD

Catalog No. BDB611847 Shop All BD Biosciences Products
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BDB611847 150 μg
BDB611846 50 μg
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Catalog No. BDB611847 Supplier BD Biosciences Supplier No. 611847

Description

Mouse Monoclonal Antibody

The SNF2-related family of proteins all contain conserved helicase motifs, and have been implicated in transcription regulation, DNA repair, and DNA recombination. The DNA-dependent ATPase activity of these proteins is usually activated by single-stranded, double-stranded, or nucleosomal DNA. The chromodomain helicase DNA binding proteins (CHDs) are a subfamily of the SNF2 family, and includes CHD1, CHD2, CHD3, and CHD4. CHD3 and CHD4 contain N-terminal paired PHD zinc finger motifs (PZF), two heterochromatin binding domains (chromodomains; CDs), and a central SNF2-like helicase/ATPase domain. CHD3 mRNA is widely expressed, and CHD3 protein localizes to the nucleus, but not nucleoli. Both CHD3 and CHD4 were first identified as self-antigens recognized by sera from patients with the autoimmune connective-tissue disease Mi-2 dermatomyositis. In addition, both CHD3 and CHD4 are associated with a nucleosome remodelling and deacetylating (NRD) complex, and facilitate deacetylation of oligonucleosomal histones in vitro. Thus, CHD3 and CHD4 are chromodomain containing proteins that may have important roles in ATP-dependent nucleosome remodelling.

Host Species: Mouse
Clone: 44
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human CHD3 aa. 1277-1474

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen CHD3
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone 44
Concentration 250μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Human CHD3 aa. 1277-1474
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Isotype IgG1
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For Research Use Only.

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