MilliporeSigma™ anti-CHIP, Polyclonal

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ PC711100UL

Catalog No. PC711100UL

Description

Specifically detects CHIP Clone: in Drosophila, Hamster, Human, Monkey, Mouse, Rat samples, and it is validated for Immunofluorescence, Immunoprecipitation

CHIP is a U-box dependent E3 ubiquitin ligase and a co-chaperone protein that interacts with Hsc70 and Hsp90 regulating protein triage decisions between folding and degradation. This occurs through CHIP remodeling the complexes to favor substrate degradation thus providing a molecular link between the chaperone and proteosome machinery. CHIP has been reported to be involved in the degradation of c-ErbB2/c-Neu, the glucocorticoid receptor, and the cystic fibrosis transmembrane-conductance regulator. CHIP expression shortens the half-life of both the nascent and mature ErbB2 protein.

Specifications

• Antigen: CHIP
• Classification: Polyclonal
• Formulation: Undiluted serum.
• Immunogen: a recombinant protein consisting of full-length human CHIP fused to a His·Tag™ sequence
• Regulatory Status: RUO
• Test Specificity: Recognizes the ∽35kDa CHIP protein. May also detect bands at ∽43, ∽51, and ∽70kDa corresponding to the mono-ubiquitinated, di-ubiquitinated, and dimeric forms of CHIP, respectively.
• Content And Storage: −20°C
• Isotype: IgG

• Applications: Immunofluorescence, Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Drosophila, Hamster, Human, Monkey, Mouse, Rat
• Form: Undiluted

For Research Use Only