MilliporeSigma anti-CHIP, Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC711100UL
Specifically detects CHIP Clone: in Drosophila, Hamster, Human, Monkey, Mouse, Rat samples, and it is validated for Immunofluorescence, ImmunoprecipitationCHIP is a U-box dependent E3 ubiquitin ligase and a co-chaperone protein that interacts with Hsc70 and Hsp90 regulating protein triage decisions between folding and degradation. This occurs through CHIP remodeling the complexes to favor substrate degradation thus providing a molecular link between the chaperone and proteosome machinery. CHIP has been reported to be involved in the degradation of c-ErbB2/c-Neu, the glucocorticoid receptor, and the cystic fibrosis transmembrane-conductance regulator. CHIP expression shortens the half-life of both the nascent and mature ErbB2 protein.
|a recombinant protein consisting of full-length human CHIP fused to a His·Tag™ sequence|
|Drosophila, Hamster, Human, Monkey, Murine, Rat|
|Recognizes the ∽35kDa CHIP protein. May also detect bands at ∽43, ∽51, and ∽70kDa corresponding to the mono-ubiquitinated, di-ubiquitinated, and dimeric forms of CHIP, respectively.|
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