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MilliporeSigma™ anti-CHIP, Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC711100UL

Catalog No. PC711100UL


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Description

Description

Specifically detects CHIP Clone: in Drosophila, Hamster, Human, Monkey, Mouse, Rat samples, and it is validated for Immunofluorescence, Immunoprecipitation

CHIP is a U-box dependent E3 ubiquitin ligase and a co-chaperone protein that interacts with Hsc70 and Hsp90 regulating protein triage decisions between folding and degradation. This occurs through CHIP remodeling the complexes to favor substrate degradation thus providing a molecular link between the chaperone and proteosome machinery. CHIP has been reported to be involved in the degradation of c-ErbB2/c-Neu, the glucocorticoid receptor, and the cystic fibrosis transmembrane-conductance regulator. CHIP expression shortens the half-life of both the nascent and mature ErbB2 protein.
Specifications

Specifications

CHIP
Unconjugated
Undiluted Serum
a recombinant protein consisting of full-length human CHIP fused to a His·Tag™ sequence
100μL
−20°C
Polyclonal
Drosophila, Hamster, Human, Monkey, Murine, Rat
Immunofluorescence, Immunoprecipitation
Undiluted serum.
Rabbit
IgG
RUO
Primary
Recognizes the ∽35kDa CHIP protein. May also detect bands at ∽43, ∽51, and ∽70kDa corresponding to the mono-ubiquitinated, di-ubiquitinated, and dimeric forms of CHIP, respectively.
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