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CHX10 Sheep anti-Chicken, Human, Mouse, Rat, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA112565

Catalog No. 01-674-794



Description

Description

By Western blot, this antibody detects a ~46 kDa band. A suggested positive control for this product is rat or mouse retinal tissue lysate.

Chx10 is a 46kDa homeodomain protein of the paried-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalmus, and spinal cord.
Specifications

Specifications

CHX10
Polyclonal
Unconjugated
VSX2
Liquid
VSX2
Protein corresponding to residues 264-361 from the C terminus of human Chx10, conjugated to GST.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Chicken, Human, Mouse, Rat
Immunohistochemistry (Frozen), Western Blot
1 mg/mL
PBS with 0.08% sodium azide
Q9IAL1, P58304, Q61412
Chx10, Hox-10, Hox10, or
Sheep
IgG
250 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
12677, 171360, 338917, 395536
Documents
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