Clec12A Mouse anti-Human, FITC, Clone: 50C1, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 562569

Catalog No. BDB562569

Description

The 50C1 monoclonal antibody specifically binds to human Clec12A (C-type lectin domain family 12 member A). Clec12A is also known as myeloid inhibitory C-type lectin-like receptor (MICL), C-type lectin-like molecule 1 (CLL-1) or dendritic cell-associated lectin 2 (DCAL-2). It is expressed on a variety of cells including monocytes, macrophages, dendritic cells, and granulocytes and perhaps some NK cells. Cleck12A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. It is a 30kDa type II transmembrane glycoprotein that has one single C-type lectin-like domain and one cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). Clec12A has similarity with the β-glucan receptor (Dectin-1) and LOX-1 with high N-glycosylation. There are at least five isoforms due to alternative transcript splicing. Signaling through Clec12A can induce internalization of Cleck12A, dendritic cell maturation and the production of cytokines including IL-12. Clec12A may also serve as a negative regulator of activated leukocytes recruited to sites of inflammation

Host Species: Mouse
Clone: 50C1
Isotype: IgG2a, κ
Species Reactivity: Human
Immunogen: Human CLEC12A Transfected Cell Line

Flow Cytometry

Specifications

• Antigen: Clec12A
• Classification: Monoclonal
• Conjugate: FITC
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human CLEC12A Transfected Cell Line
• Quantity: 50 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: 50C1
• Description: CD371; Clec12A; MICL; CLL-1; DCAL-2
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG2a κ