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CD299 (DC-SIGN/L) Mouse anti-Human, Clone: 2G1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA521012

Catalog No. PIMA521012


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Description

Description

Peptide Sequence: SQRNWHDSVT ACQEVRAQLV VIKTAEEQNF LQLQTSRSNR FSWMGLSDLN QEGTWQWVDG SPLSPSFQRY WNSGEPNNSG NEDCAEFSGS GWNDNRCDVD NYWICKKPAA

This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants
Specifications

Specifications

CD299 (DC-SIGN/L)
Monoclonal
1.0 mg/mL
PBS with no preservative; pH 7.4
Q9H2X3
C-type lectin domain family 4 member M, CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, MGC129964, MGC47866
Mouse
IgG3, lambda
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
10332
ELISA, Western Blot
2G1
Unconjugated
CLEC4M
Liquid
CLEC4M
CLEC4M (NP_055072, 285 a.a. ∽ 394 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Documents
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