p21, clone: F155-227, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA191045

Catalog No. PIMA191045

Description

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

MA1-91045 detects cN RAS from rat, mouse, human samples.MA1-91045 has been successfully used in immunohistochemistry (frozen tissue), immunohistochemistry (paraffin tissue), Western blot, immunoprecipitation applications.The MA1-91045 immunogen is: Recombinant p21 protein.

Specifications

• Antigen: cN RAS
• Classification: Monoclonal
• Concentration: 0.1mg/mL
• Gene: CDKN1A
• Gene Alias: CAP20, CDKN1, CDNK1A, MDA-6, SDI1, WAF1, p21CIP1, CDK-interacting protein 1, CDK-interaction protein 1, DNA synthesis inhibitor, cyclin-dependent kinase inhibitor 1, melanoma differentiation associated protein 6, wild-type p53-activated fragment 1
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 1026
• Content And Storage: Store at 4°C, do not freeze
• Form: Purified

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: F155-227
• Conjugate: Unconjugated
• Gene Accession No.: P38936, P39689
• Gene Symbols: CDKN1A
• Immunogen: Recombinant p21 protein.
• Quantity: 25 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1 κ