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MilliporeSigma™ anti-Complement 3, Polyclonal

Catalog No. 2048691ML Shop All MilliporeSigma Products
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1 mL
Conjugate:
Unconjugated
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20-486-91ML 1 mL Unconjugated
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Catalog No. 20-486-91ML Supplier MilliporeSigma™ Supplier No. 2048691ML
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Description

Goat Polyclonal Antibody

Specifically detects Complement 3 Clone: in Baboon, Equine, Guinea Pig, Hamster, Human, Mouse, Rabbit, Rat samples, and it is validated for Flow Cytometry, Immunocytochemistry, Immunoelectrophoresis, Immuno Blotting

The complement system provides innate defense against microbial infection and is a complement to antibody mediated immunity. The complement system consists of thirty five interacting plasma and membrane associated proteins which contribute to host-defense and initiate and amplify inflammation, even in the preimmune state where specific antibodies and lymphocytes are not available. In addition to the complement components themselves, this system also contains several soluble factors that prevent spontaneous complement activation from occurring in solution, as well as, several regulatory membrane associated proteins that protect host cells from accidental complement attack. Cleavage of the C3 component by either the classical pathway or the alternative pathway releases C3a and C3b. C3a appears to be important in many inflammatory responses while the C3b fragment covalently binds to the cell or bacterial surface and plays a role in opsonisation. Binding of C3b to the C4b component of the C3 convertase, results in C5 convertase (C4b3b2a) formation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Complement 3
Applications Flow Cytometry, Immunoblot, Immunoblot, Immunocytochemistry, Immunoelectrophoresis
Classification Polyclonal
Conjugate Unconjugated
Formulation Serum diluted in 500mM NaCl, 50mM Tris-HCl, pH 7.5.
Host Species Goat
Immunogen purified, human C3 complement component
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Monospecific for C3 complement component. May also recognize C3 fragments, C3a, C3b, and C3c.
Target Species Baboon, Equine, Guinea Pig, Hamster, Human, Mouse, Rabbit, Rat
Content And Storage −20°C
Form Undiluted
Isotype IgG
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