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COMT Mouse, Unlabeled, Clone: 4, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611970

Catalog No. BDB611970


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Description

Description

Catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) are the major mammalian enzymes involved in the degradation of the catecholamine neurotransmitters, dopamine, norepinephrine, and epinephrine. COMT is a Mg2+-dependent enzyme that catalyzes the transfer of methyl groups from S-adenosyl methionine to a hydroxyl group of a catecholic substrate. Two forms of COMT are found in rat brain, a 24kDa soluble COMT (S-COMT) and a 28kDa membrane-bound COMT (MB-COMT). COMT is widely expressed in brain, but its importance in catecholamine neurotransmitter degradation relative to MAO varies in different brain regions. In addition, COMT may function primarily in extraneuronal areas, such as in glial cells and postsynaptic neurons. COMT-deficient mice have sex- and region-specific alterations in dopamine levels in the brain, and display impaired emotional reactivity and aggressive behavior. Thus, COMT-mediated degradation of catecholamines in the brain may have important roles in maintaining normal catecholamine levels, as well as normal social behavior.

Host Species: Mouse
Clone: 4
Isotype: IgG1
Species Reactivity [for Features Main]: Rat
Immunogen: Mouse COMT aa. 26-141

Western Blotting

Specifications

Specifications

COMT
4
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Catechol-O-Methyltransferase
Affinity Purified
Mouse COMT aa. 26-141
50μg
Cell Biology
Primary
Murine, Rat
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