COMT Mouse, Unlabeled, Clone: 4, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611970
Catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) are the major mammalian enzymes involved in the degradation of the catecholamine neurotransmitters, dopamine, norepinephrine, and epinephrine. COMT is a Mg2+-dependent enzyme that catalyzes the transfer of methyl groups from S-adenosyl methionine to a hydroxyl group of a catecholic substrate. Two forms of COMT are found in rat brain, a 24kDa soluble COMT (S-COMT) and a 28kDa membrane-bound COMT (MB-COMT). COMT is widely expressed in brain, but its importance in catecholamine neurotransmitter degradation relative to MAO varies in different brain regions. In addition, COMT may function primarily in extraneuronal areas, such as in glial cells and postsynaptic neurons. COMT-deficient mice have sex- and region-specific alterations in dopamine levels in the brain, and display impaired emotional reactivity and aggressive behavior. Thus, COMT-mediated degradation of catecholamines in the brain may have important roles in maintaining normal catecholamine levels, as well as normal social behavior.
Host Species: Mouse
Species Reactivity [for Features Main]: Rat
Immunogen: Mouse COMT aa. 26-141
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|Mouse COMT aa. 26-141|
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