Connexin-43 Mouse, Unlabeled, Clone: 2, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610061
Gap junctions are intercellular protein pores. They enable cell-to-cell communication by allowing passage of ions and other small molecules. The subunits of gap junction channels are assembled from a family of proteins called connexins. Individual connexin molecules join to make hexameric hemichannels termed connexons; these structures dock to connexons on neighboring cells, forming gap junction pores. Connexin-43 is a member of the connexin family possessing four transmembrane regions, with cytoplasmic amino and carboxyl terminals. It undergoes rapid turnover in the cell and its monomers may reside in the ER/Golgi network, forming a reservoir available for assembly upon
degradation of existing connexin-43 channels. In addition, it is believed that phosphorylation of connexin-43 plays a regulatory role both in the assembly of connexons and in gating activity at the gap junction.
Host Species: Mouse
Species Reactivity: Rat
Immunogen: Rat Connexin-43 aa. 252-270
Formula Weight [Chemical]: 43kDa
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
|Rat Connexin-43 aa. 252-270|
|Canine, Chicken, Human, Murine, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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For Research Use Only.