Coronin 1A Rabbit anti-Bovine, Human, Mouse, Porcine, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA110022
DescriptionHighly conserved coronin family of proteins/actin regulators from WD-repeat superfamily were originally identified in Dictyostelium, wherein, coronin deletions were observed to affect actin-dependent processes, such as phagocytosis, cell motility, and cytokinesis. Coronin-1A (Coro1A) belongs to Type I coronins, almost exclusively expressed in hematopoietic lineages, and plays a key role during T lymphocyte activation, migration, survival, and calcium signaling. Moreover, Coronin-1A has been documented to be dispensable for actin-dependent functions in macrophages. Coro1a-deficient mice have reduced peripheral T cells due to both an impaired survival of naive cells and migrational defects. Both CD4+ and CD8+ T cell subsets are decreased in the periphery of Coro1a-/- mice while thymic cellularity and subpopulations are similar to those observed in wild-type mice. A nonsense mutation in Coro1a has been shown to protect against systemic lupus in a mouse model. Moreover, it has shown that Coro1a is mutated in a thymic egress-deficient mouse strain, but also in a patient with severe combined immunodeficiency (SCID).
|C-terminal peptide of human coronin 1a coupled to KLH|
|Bovine, Human, Mouse, Porcine, Rat|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 50% glycerol and 5mM sodium azide|
|Q92176, P31146, O89053, Q91ZN1|
|CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|282196, 12721, 155151, 11151, 100621483|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok