anti-Coronin 1a Polyclonal, Thermo Scientific™

Coronin 1a Polyclonal Ab PA1-10007 from Thermo Scientific™ specifically detects Coronin 1a in Hu, Ms and Rt samples, and it is validated for ICC, IF and WB

Manufacturer: Invitrogen PA110022

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Catalog No. 01-670-279

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    Specifications

    Antigen Coronin 1a
    Applications Immunocytochemistry,Immunofluorescence,Immunohistochemistry,Western Blot
    Conjugate Unlabeled
    Cross Reactivity Bovine,Chicken,Equine,Human,Mouse,Porcine,Rat
    Format Serum
    Formulation 100μL unpurified antibody in whole serum and no preservative
    Gene Accession No. O89053, P31146, Q91ZN1, Q92176
    Gene Alias CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57
    Gene Symbols CORO1A
    Host Species Rabbit
    Immunogen Full-length recombinant human Coronin 1a
    Isotype IgG
    Quantity 100μL
    Species Reactivity Bovine, Chicken, Equine, Human, Mouse, Porcine, Rat
    Storage Requirements avoiding freeze/thaw cycles.
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal
    Gene ID (Entrez) 100064170, 100621483, 11151, 12721, 155151, 282196

    Coronin 1a Polyclonal Ab PA1-10007 from Thermo Scientific™ specifically detects Coronin 1a in Hu, Ms and Rt samples, and it is validated for ICC, IF and WB

    Highly conserved coronin family of proteins/actin regulators from WD-repeat superfamily were originally identified in Dictyostelium, wherein, coronin deletions were observed to affect actin-dependent processes, such as phagocytosis, cell motility, and cytokinesis. Coronin-1A (Coro1A) belongs to Type I coronins, almost exclusively expressed in hematopoietic lineages, and plays a key role during T lymphocyte activation, migration, survival, and calcium signaling. Moreover, Coronin-1A has been documented to be dispensable for actin-dependent functions in macrophages. Coro1a-deficient mice have reduced peripheral T cells due to both an impaired survival of naive cells and migrational defects. Both CD4+ and CD8+ T cell subsets are decreased in the periphery of Coro1a-/- mice while thymic cellularity and subpopulations are similar to those observed in wild-type mice. A nonsense mutation in Coro1a has been shown to protect against systemic lupus in a mouse model. Moreover, it has shown that Coro1a is mutated in a thymic egress-deficient mouse strain, but also in a patient with severe combined immunodeficiency (SCID).
    Host Species: Rabbit
    Cross Reactivity: Bovine, Chicken, Equine, Human, Mouse, Porcine, Rat
    Isotype: IgG
    Immunogen: Full-length recombinant human Coronin 1a
    Formulation: 100µL unpurified antibody in whole serum and no preservative
    Synonyms: CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57
    Uniprot Accession: O89053, P31146, Q91ZN1, Q92176
    Entrez GeneID: 100064170, 100621483, 11151, 12721, 155151, 282196
    Gene Symbol: CORO1A
    This product detects Coronin 1a in Bovine, Chicken, Equine, Human, Mouse, Porcine and Rat samples. This product has been successfully used in Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western Blot procedures. The immunogen is Full-length recombinant human Coronin 1a.
    References:
    Test: ICC, Dilution: 1:500, Species: Rt, Reference: The effect of simvastatin on the proteome of detergent-resistant membrane domains: decreases of specific proteins previously related to cytoskeleton regulation, calcium homeostasis and cell fate. (2010 May) Proteomics, Vol: 10, 10, 1954-65, Ponce J, Brea D, Carrascal M, Guirao V, Degregorio-Rocasolano N, Sobrino T, Castillo J, Dávalos A, Gasull T; Pubmed ID: 20217863

  • Description & Specifications

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