MilliporeSigma™ anti-COUP-TF1, Polyclonal

Catalog No.	Quantity	Conjugate
ABE1425MI	100 μL	Unconjugated

Catalog No. ABE1425MI Supplier MilliporeSigma™ Supplier No. ABE1425

Description

Rabbit Polyclonal Antibody

Specifically detects COUP-TF1 Clone: in Human, Mouse, Rat samples, and it is validated for Chromatin Immunoprecipitation, Immunofluorescence, Immunohistochemistry, Western Blotting

COUP transcription factor 1 (UniProt Q60632; also known as Avian erythroblastic leukemia viral oncogene homolog-like 3, COUP-TF1, COUP-TF I, COUP transcription factor I, EAR-3, Nuclear receptor subfamily 2 group F member 1, V-erbA-related protein 3) is encoded by the Nr2f1 (also known as Erbal3, Tfcoup1) gene (Gene ID 13865) in murine species. COUP transcription factors1&2 (COUP-TFI, COUP-TFII) are two related nuclear orphan receptors implicated in their roles in guiding migrating neurons towards their target regions during brain development. COUP-TFI and COUP-TFII are expressed in distinct and non-overlapping migrating cells in specific pathways in the basal telencephalon of mouse embryos at a stage when interneuron migration is robust. While COUP-TFI appears to control dorsal and ventral migration in the basal telencephalon, COUP-TFII is more specific in modulating tangential migration into the intermediate zone of the cortex. Coup-TFII is also identified as an activator of Prox1 expression in venous lymphatic endothelial cell (LEC) progenitors during early stages of LEC specification and differentiation.

Specifications

• Antigen: COUP-TF1
• Applications: ChIP Assay, Immunofluorescence, Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: Rabbit polyclonal antibody in serum with 0.05% sodium azide.
• Gene Accession No.: Q60632
• Gene Symbols: Nr2f1, Erbal3, Tfcoup1
• Host Species: Rabbit
• Immunogen: GST-tagged recombinant protein corresponding to the N-terminal half of mouse COUP-TF1.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Epigenetics, Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_034281
• Test Specificity: Specificity of the antiserum was confirmed by immunogen blocking in immunohistochemistry on frozen sections (Tripodi, M., et al. (2004). Development. 131(24):6119-6129).
• Target Species: Human, Mouse, Rat
• Content And Storage: −20°C for one year
• Form: Serum

For Research Use Only