Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. BDB565125

COX-2 Mouse anti-Human, PE, Clone: AS67, BD

Catalog No. BDB565125 Shop All BD Biosciences Products
Change view
Click to view available options
Quantity:
50 Tests
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
BDB565125 50 Tests
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. BDB565125 Supplier BD Biosciences Supplier No. 565125
Add to Cart
Add to Cart

Description

Mouse Monoclonal Antibody

The AS67 monoclonal antibody specifically binds to Cyclooxygenase-2 (COX-2/COX2) which is also known as, Prostaglandin G/H synthase 2 (PGHS-2). The COX-2 enzyme is encoded by the PTGS2 gene, Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) and exists as a homodimer that is located on the lumenal surface of the endoplasmic reticulum and on the inner and outer membranes of the nuclear envelope. COX-2 catalyzes the conversion of arachidonic acid into prostaglandin H2 (PGH2). Specific prostaglandin synthases then convert the PGH2 intermediate into various biologically active prostanoids, including Prostaglandin E2 (PGE2) and Thromboxane A2 (TXA2). COX-2 expression is not detected in most tissues under physiological conditions . However, COX-2 expression is rapidly upregulated during the course of inflammation, following cellular stresses, and in response to growth factors, tumor promoters, hormones, bacterial endotoxins, and inflammatory cytokines, eg, Interleukin-1α (IL-1α). C OX-2 can be induced in a number of cell types, including fibroblasts, endothelial cells, monocytes, ovarian follicles and mesenchymal stromal cells. Although COX-2 is structurally homologous to Cyclooxygenase-1 (COX-1), the AS67 antibody does not crossreact with recombinant human COX-1 protein as tested by immunoassay.

TRUSTED_SUSTAINABILITY

Specifications

Antigen COX-2
Applications Flow Cytometry
Classification Monoclonal
Clone AS67
Conjugate PE
Description hCox-2; COX2; PTGS2; PGG/HS; PGHS-2; PHS-2; GRIPGHS
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide
Host Species Mouse
Immunogen Human COX-2 Recombinant Protein
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.