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COX2 Mouse anti-Human, FITC, Clone: AS66, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112235

Catalog No. 01-670-943

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody does not cross-react with human COX-1 in ELISA applications.

Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the of conversion arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2, PGE2, PGF2a, PGI2 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. There are two enzymes of COX, COX-1 and COX-2. COX-1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL-1beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX-2. COX-2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX-2.
Specifications

Specifications

COX2
Monoclonal
FITC
PTGS2
Liquid
PTGS2
Human recombit COX2 protein.
Protein A/G
RUO
Antibody
Monoclonal
Human
Flow Cytometry
AS66
PBS with 0.2% carrier protein and 0.08% sodium azide
P35354
PTGS2, prostaglandin-endoperoxide synthase 2, prostaglandin G/H synthase, cyclooxygenase, COX-2, PHS-2, PGG/HS, PGHS-2, hCox-2
Mouse
IgG1
100 Tests
4° C, do not freeze
Primary
5743
Documents
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