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Invitrogen™ Nesprin 1 Monoclonal Antibody (6A)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA113082

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Catalog No. PIMA113082


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Description

Description

Nesprin 1 Monoclonal Antibody for Western Blot

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Nesprin 1
Monoclonal
1 mg/mL
PBS with 1 mg/mL BSA and 0.05% sodium azide
Q6ZWR6
SYNE1
Recombinant protein containing residues RKLESTLTGLEQSRERQERR.
100 μg
Primary
Mouse, Rat
Antibody
IgG1
Western Blot
6A
Unconjugated
SYNE1
8B; A330049M09Rik; ARCA1; BE692247; C130039F11Rik; C6orf98; CPG2; CPG2 full length; dJ45H2.2; DKFZp781J13156; EDMD4; enaptin; enaptin165; FLJ30878; FLJ41140; KASH domain-containing protein 1; KASH1; KIAA0796; KIAA1262; KIAA1756; mKIAA1756; MYNE1; Myne-1; Myocyte nuclear envelope protein 1; Nesp1; nesprin 1; nesprin-1; Nuclear envelope spectrin repeat protein 1; RP1-130E4.2; SCAR8; spectrin repeat containing nuclear envelope protein 1; spectrin repeat containing, nuclear envelope 1; synaptic nuclear envelope 1; synaptic nuclear envelope protein 1; synaptic nuclei expressed gene 1; SYNE 1; SYNE1; Syne-1; syne-1 fragment
Mouse
Protein G
RUO
499010, 64009
-20°C
Liquid
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