Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ Nesprin 1 Monoclonal Antibody (6A)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA113082
Description
Nesprin 1 Monoclonal Antibody for Western Blot
There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.
Specifications
Nesprin 1 | |
Monoclonal | |
1 mg/mL | |
PBS with 1 mg/mL BSA and 0.05% sodium azide | |
Q6ZWR6 | |
SYNE1 | |
Recombinant protein containing residues RKLESTLTGLEQSRERQERR. | |
100 μg | |
Primary | |
Mouse, Rat | |
Antibody | |
IgG1 |
Western Blot | |
6A | |
Unconjugated | |
SYNE1 | |
8B; A330049M09Rik; ARCA1; BE692247; C130039F11Rik; C6orf98; CPG2; CPG2 full length; dJ45H2.2; DKFZp781J13156; EDMD4; enaptin; enaptin165; FLJ30878; FLJ41140; KASH domain-containing protein 1; KASH1; KIAA0796; KIAA1262; KIAA1756; mKIAA1756; MYNE1; Myne-1; Myocyte nuclear envelope protein 1; Nesp1; nesprin 1; nesprin-1; Nuclear envelope spectrin repeat protein 1; RP1-130E4.2; SCAR8; spectrin repeat containing nuclear envelope protein 1; spectrin repeat containing, nuclear envelope 1; synaptic nuclear envelope 1; synaptic nuclear envelope protein 1; synaptic nuclei expressed gene 1; SYNE 1; SYNE1; Syne-1; syne-1 fragment | |
Mouse | |
Protein G | |
RUO | |
499010, 64009 | |
-20°C | |
Liquid |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction