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CREB Mouse anti-Human, Mouse, Non-human primate, Rat, Clone: LB9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA1083

Catalog No. 01-670-102


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Description

Description

MA1-083 detects the CREB in human, monkey, rat and mouse cells. MA1-083 has been successfully used in immunofluorescence, Western blot, immunoprecipitation, immunohistochemistry, and ELISA procedures. By Western blot, this antibody detects a ~43 kDa protein. The MA1-083 immunogen is human recombit CREB-A protein.

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.
Specifications

Specifications

CREB
Monoclonal
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P16220, Q01147, P15337
Cyclic AMP Response Element Binding Protein
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
12912, 1385, 81646
ChIP assay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
LB9
Unconjugated
CREB1
Liquid
CREB1
Recombit human CREB-A protein.
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Non-human primate, Rat
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