CRTH2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520332
A suggested positive control is Jurkat cell lysate. PA5-20332 can be used with blocking peptide PEP-0452.The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist.
|An 18 amino acid peptide from near the amino terminus of human CRTH2.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q13258, Q9Y5Y4, P70263, Q9Z2J6, Q6XKD3, Q9R261|
|CD294, CRTH2, DL1R, DP2, GPR44, G protein-coupled receptor 44, G Protein-Coupled Rec. 44|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|11251, 14764, 19214, 309212, 498475, 5729|
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