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CRTH2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520332

Catalog No. PIPA520332


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Description

Description

A suggested positive control is Jurkat cell lysate. PA5-20332 can be used with blocking peptide PEP-0452.

The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist.
Specifications

Specifications

CRTH2
Polyclonal
Unconjugated
PTGDR2
Liquid
PTGDR, PTGDR2
An 18 amino acid peptide from near the amino terminus of human CRTH2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q13258, Q9Y5Y4, P70263, Q9Z2J6, Q6XKD3, Q9R261
CD294, CRTH2, DL1R, DP2, GPR44, G protein-coupled receptor 44, G Protein-Coupled Rec. 44
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
11251, 14764, 19214, 309212, 498475, 5729
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