CRYBB1, Mouse, Clone: 3D9, Abnova™

Catalog No.	Quantity
89-021-173	100 μg

Catalog No. 89-021-173 Supplier Abnova Corporation Supplier No. H00001414M03

Description

Mouse monoclonal antibody raised against a partial recombinant CRYBB1.

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3. [provided by RefSeq

Sequence: TTLAPTTVPITSAKAAELPPGNYRLVVFELENFQGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSSSYRSDRLM

Specifications

• Antigen: CRYBB1
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 3D9
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant CRYBB1.
• Formulation: PBS with no preservative; pH 7.4
• Gene: CRYBB1
• Gene Accession No.: NM_001887
• Gene Alias: CATCN3
• Gene Symbols: CRYBB1
• Host Species: Mouse
• Immunogen: CRYBB1 (NP_001878, 37 a.a. ∼ 137 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1414
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b κ