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Csk Mouse, Unlabeled, Clone: 52, BD

Mouse Monoclonal Antibody

$225.00 - $415.00


Antigen Csk
Isotype IgG1
Immunogen Rat Csk aa. 1-156
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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BD Biosciences
50μg Each for $225.00
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150μg Each for $415.00
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The csk gene encodes a protein kinase that phosphorylates several Src family kinases including p60(c-src), p59(fyn), p53/56(lyn), p56(lck), and p62(yes). This phosphorylation occurs specifically at the carboxy-terminal tyrosine, Y527. Csk (c-src kinase) was identified based on its ability to phosphorylate exogenous Src in mammalian src-deficient cells. Establishment of a mouse csk- cell line revealed that phosphorylation of Y527 in Src was reduced 20-50%. This correlated with an increase of Src kinase activity, thus indicating Csk is a negative regulator of src. Csk-deficient cells also show an elevation in the kinase activity of p59(fyn) and p53/56(lyn). These data suggest that Csk may be a universal negative regulator of Src family kinases in vivo.

Host Species: Mouse
Clone: 52
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Rat Csk aa. 1-156
Formula Weight [Chemical]: 50kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting



Rat Csk aa. 1-156
Cell Biology
Affinity Purified
Store undiluted at -20°C.
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Western Blot

For Research Use Only.

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