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Csk Mouse, Unlabeled, Clone: 52, BD
Mouse Monoclonal Antibody
$225.00 - $415.00
Specifications
| Antigen | Csk |
|---|---|
| Isotype | IgG1 |
| Immunogen | Rat Csk aa. 1-156 |
| Formulation | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| Conjugate | Unconjugated |
Description
The csk gene encodes a protein kinase that phosphorylates several Src family kinases including p60(c-src), p59(fyn), p53/56(lyn), p56(lck), and p62(yes). This phosphorylation occurs specifically at the carboxy-terminal tyrosine, Y527. Csk (c-src kinase) was identified based on its ability to phosphorylate exogenous Src in mammalian src-deficient cells. Establishment of a mouse csk- cell line revealed that phosphorylation of Y527 in Src was reduced 20-50%. This correlated with an increase of Src kinase activity, thus indicating Csk is a negative regulator of src. Csk-deficient cells also show an elevation in the kinase activity of p59(fyn) and p53/56(lyn). These data suggest that Csk may be a universal negative regulator of Src family kinases in vivo.
Host Species: Mouse
Clone: 52
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Rat Csk aa. 1-156
Formula Weight [Chemical]: 50kDa
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Specifications
| Csk | |
| Rat Csk aa. 1-156 | |
| Unconjugated | |
| Cell Biology | |
| Murine | |
| Affinity Purified | |
| Monoclonal | |
| Store undiluted at -20°C. |
| IgG1 | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Primary | |
| Western Blot | |
| RUO | |
| 52 | |
| 250μg/mL |
For Research Use Only.
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