Cutaneous Lymphocyte Antigen Rat anti-Human, Alexa Fluor 647, Clone: HECA-452, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 563533
The HECA-452 monoclonal antibody specifically reacts with Cutaneous Lymphocyte Associated Antigen (CLA), a carbohydrate domain shared by sialyl Lewis[x] (sLe[x]) and sialyl Lewis[a] (sLe[a]) antigens. It serves as a ligand for selectins including CD62E (E-selectin; ELAM-1). CLA is expressed on high endothelium and on lymphocytes including most T lymphocytes infiltrating cutaneous sites of inflammation. Amongst peripheral blood cells, it is expressed on monocytes and granulocytes and a subset of lymphocytes. The HECA-452 antibody is also reportedly crossreactive with the mouse CLA carbohydrate epitope that is transiently expressed by PSGL-1/CD162 on activated T cells. A number of studies suggest that CLA plays an important role in supporting leucocyte adhesive interactions and migration into extravascular tissues during inflammation.
|Cutaneous Lymphocyte Antigen|
|CLA; PSGL-1; CD162; P-selectin glycoprotein ligand 1; SELPL; SELPLG|
|Lymphocyte-depleted Stromal Preparation of Tonsil|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Alexa Fluor 647|
|Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.|
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