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CXCR2, Rabbit, Monoclonal Antibody, Abnova™

Catalog No. 89200049 Shop All Abnova Corporation Products
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1 mg x up to 3 Abs
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Catalog No. Quantity
89-200-049 1 mg x up to 3 Abs
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Catalog No. 89-200-049 Supplier Abnova Corporation Supplier No. H00003579K

Description

Includes

Up to three rabbit IgG clones of 1mg each will be delivered to customer.

Rabbit monoclonal antibody raised against a human CXCR2 peptide using ARM Technology.

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq

Library Construction: Nonfusion antibody library from rabbit spleen (ARM Technology)
Expression: Overexpression vector and transfection into 293H cell line

Order Info

  1. Customer may provide cell or tissue lysate for antibody screening.
  2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.

Specifications

Antigen CXCR2
Applications ELISA, Western Blot
Classification Monoclonal
Concentration 1mg
Conjugate Unconjugated
Description chemokine (C-X-C motif) receptor 2
Formulation In 1X PBS, pH 7.4
Gene CXCR2
Gene Accession No. CXCR2
Gene Alias CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Gene Symbols CXCR2
Host Species Rabbit
Immunogen A synthetic peptide of human CXCR2
Quantity 1 mg x up to 3 Abs
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3579
Target Species Human
Content And Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG
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