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MilliporeSigma™ anti-CXCR4 Clone: 12G5,

Catalog No. MABF981MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABF981MI 100 μg Unconjugated
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Catalog No. MABF981MI Supplier MilliporeSigma™ Supplier No. MABF981
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Description

Mouse Monoclonal Antibody

Specifically detects CXCR4 Clone: 12G5 in Human samples, and it is validated for Flow Cytometry, Immunocytochemistry, Neutralization

C-X-C chemokine receptor type 4 (UniProt P61073; also known as CD184, CXC-R4, CXCR-4, FB22, Fusin, HM89, LAP-3, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor, Lipopolysaccharide-associated protein 3, LPS-associated protein 3, Neuropeptide Y receptor Y3, NPYRL, SDF-1 receptor, Stromal cell-derived factor 1 receptor) is encoded by the CXCR4 (also known as D2S201E, HSY3RR, LAP3, NPY3R, NPYR, NPYY3R, WHIM, WHIMS) gene (Gene ID 7592) in human. Chemokines and their receptors direct migration of distinct leukocyte subsets to sites of inflammation and to their specific niches in lymphoid organs. Virtually all T cell chemoattractants selectively attract memory/activated T cells. CXCR4 is the seven-transmembrane receptor for SDF-1 that is essential for the development of non-hematopoietic tissues, including heart and B lymphocytes. CXCR4 and CCR5 are two chemokine receptors that also function as co-receptors for human immunodeficiency virus (HIV) entry into CD4+ cells. During the early stages of HIV infection, viral isolates tend to use CCR5 for viral entry, while later isolates tend to use CXCR4.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CXCR4
Applications Flow Cytometry, Immunocytochemistry, Neutralization
Classification Monoclonal
Clone 12G5
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgG2aκ antibody in PBS without preservatives.
Gene Accession No. P61073
Gene Symbols CXCR4
Host Species Mouse
Immunogen Simian immunodeficiency virus (SIVmac) variant CP-MAC-infected Sup-T1 human T lymphoblasts.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation, Immunology
Primary or Secondary Primary
Gene ID (Entrez) NP_001008540
Target Species Human
Content And Storage -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Form Purified
Isotype IgG2a κ
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For Research Use Only

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