Cyclin B1 (a.a 1-21) with control Mouse anti-Human, PE, Clone: GNS-1, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 550783

Catalog No. BDB550783

Description

Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. The main cyclin-cdks complexes formed in vertebrae cells are cyclin-cdks complexes that regulate the progression of the cell cycle. The main cyclin-cdks complexes formed in vertebrae cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27[Kip1]. Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (e.g., c-abl and SV40) large T-Ag), tumor suppressor genes (e.g., retinoblastoma protein, Rb) nucleolin and others. Cyclin B1 is a mitotic cyclin complex; expression is normally low in G0/G1, increases in S, and is maximal during G2/M. Cyclin B1 is rapidly degraded at the end of mitosis and is required for cells to exit from mitosis. Clone GNS-1 recognizes an epitope between amino acids 1-21 of human Cyclin B1. GNS-1 crossreacts with hamster and mouse cyclin B1 by western blot analysis; however, it has not been evaluated for crossreactivity by flow cytometry. Recombinant human cyclin B1 was used as immunogen.

Specifications

• Antigen: Cyclin B1 (a.a 1-21) with control
• Classification: Monoclonal
• Conjugate: PE
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Includes: PE Mouse Anti-Human Cyclin B1 (100 tests), PE Mouse IgG1 κ Isotype Control (100 tests)
  
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: GNS-1
• Host Species: Mouse
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Isotype: IgG1

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.