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Cyclin B1 Mouse, Unlabeled, Clone: GNS-1, BD

Catalog No. BDB554177 Shop All BD Biosciences Products
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BDB554177 0.25 mg
BDB554176 0.1 mg
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Catalog No. BDB554177 Supplier BD Biosciences Supplier No. 554177
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Description

Mouse Monoclonal Antibody

Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins (regulatory subunits) bind to cdks (catlytic subunits) to form complexes that regulate the progression of the cell cycle. The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins, such as p21 and p27 [Kip1]. Cyclin B1 is a mitotic cyclin, where expression is normally low in G0/G1, increases in S and is maximal during the G2/M phase. Cyclin B1 is rapidly degraded at the end of mitosis, and is required for cells to exit from mitosis. This antibody has been reported to react to hamster and mouse cyclin B1. In addition, the GNS-1 antibody has been reported to recognize an epitope between amino acids 1-21 of human cyclin B1.

Host Species: Mouse
Clone: GNS-1
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Cyclin B1 Recombinant Protein
Formula Weight [Chemical]: 62kDa

Bioimaging, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Cyclin B1
Applications Western Blot
Classification Monoclonal
Clone GNS-1
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Cyclin B1 Recombinant Protein
Purification Method Affinity Purified
Quantity 0.25 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Hamster, Human, Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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