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Cyclin B1 Mouse, Unlabeled, Clone: GNS-11, BD

Catalog No. BDB554178 Shop All BD Biosciences Products
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BDB554178 0.1 mg
BDB554179 0.25 mg
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Catalog No. BDB554178 Supplier BD Biosciences Supplier No. 554178

Description

Mouse Monoclonal Antibody

During the cell cycle, most eukaryotic cells double in mass, replicate their DNA and then distribute identical copies of their genome to progeny cells during mitosis. An internal biochemical clock ensures that all the necessary events occur in proper sequence and at the appropriate time. Cell in M phase contain a dominant regulatory factor known as maturation promoting factor (MPF). MPF triggers a variety of enzymatic and ultrastructural changes that are necessary for cell division. In higher eukaryotes, these mitosis-specific alterations include disassembly of the nuclear envelope, packaging of the DNA into chromosomes and assembly of the mitotic spindle. Purified MPF is a regulator of a protein kinase cascade and is evolutionarily conserved in all eukaryotic cells ranging from yeast to man. MPF consists predominantly of two polypeptides, cyclin B1 and p34, and contains protein kinase activity itself. It is the major M-phase-specific histone H1 kinase, but also phosphorylates a variety of other substrates including lamins, nucleolin, RNA polymerase II, retinoblastoma protein, SV40 large T antigen, p53, and the oncogenes c-src and c-abl. Cyclin B1 migrates at a reduced molecular weight of 62kDa on SDS-PAGE.

Host Species: Mouse
Clone: GNS-11
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Recombinant Human Cyclin B1
Formula Weight [Chemical]: 62kDa

Bioimaging, Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Cyclin B1
Applications Western Blot
Classification Monoclonal
Clone GNS-11
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Recombinant Human Cyclin B1
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a
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For Research Use Only.

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