Cyclin E Mouse anti-Human, Unlabeled, Clone: HE12, BD

Catalog No.	Quantity
BDB551159	50 μg

Catalog No. BDB551159 Supplier BD Biosciences Supplier No. 551159

Description

Mouse Monoclonal Antibody

Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small proteins that bind to cyclins, cdks, or cyclin-cdk complexes, e.g., p21 and p27 [Kip1]. Cyclin E is expressed in G1 and associates with cdk2 to form an active kinase where it plays an important role in the regulation of the G1/S restriction checkpoint in the cell cycle. Abberant expression of cyclin E has been reported to be associated with the oncogenic transformation of cells. This antibody has been reported not to cross-react with mouse cyclin E.

Specifications

• Antigen: Cyclin E
• Applications: Western Blot
• Classification: Monoclonal
• Clone: HE12
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Quantity: 50 μg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at -20°C.
• Isotype: IgG1

For Research Use Only.