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Cytokeratin 7 Mouse, Unlabeled, Clone: RCK105, BD

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BDB550507 50 μg
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Catalog No. BDB550507 Supplier BD Biosciences Supplier No. 550507

Description

Mouse Monoclonal Antibody

Intermediate filaments (IF) are a subset of cytoskeletal proteins which function to give overall structural integrity to the plasma membrane as well as organize cells into specific tissues. IF proteins can be divided into six major types based upon the similarity in sequence. Type I and II IF proteins are designated keratins based upon whether they are acidic (I) or basic (II) and are characterized by their remarkable biochemical diversity. A subgroup of keratins, designated cytokeratins, are represented in epithelial tissues by at least 20 different polypeptides, designated
1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin 5 has a molecular weight of approximately 58kDa (NCBI Accession number P13647) while cytokeratin 8 is approximately 53kDa (NCBI Accession number P05787). We observe cytokeratin 5 to migrate at approximately 54kDa and cytokeratin 8 at approximately 52kDa. The antibody recognizes cytokeratins 5 and 8 from human, mouse, rat, hamster, rabbit, canine, and swine. The antibody stains all epithelial tissue; it does not stain non-epithelial tissue. The human lung cancer cell line (MR21) was used as the immunogen.

Host Species: Mouse
Clone: RCK102
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human lung cancer cell line (MR21)

Immunohistochemistry (Frozen), Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Cytokeratin 7
Applications Western Blot
Classification Monoclonal
Clone RCK105
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human lung cancer cell line (MR21)
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Hamster, Human, Mouse, Pig, Rat
Content And Storage Store undiluted at 4°C
Isotype IgG1
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For Research Use Only.

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