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DACT1 Rabbit anti-Chicken, Human, Mouse, Non-human primate, Rat, Xenopus laevis, Zebrafish, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523216

Catalog No. PIPA523216


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Description

Description

Dapper homolog 1, an ortholog of Xenopus Dpr, antagonizes Wnt signaling by promoting Dvl degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism. Dapper homolog 1 acts as an interacting protein for Dvl, and the interaction is formed between the DEP (Dishevelled, Egl-10, and pleckstrin) domain of Dvl and the central and C-terminal regions of Dapper homolog 1. The gene for human Dapper homolog 1 is localized on chromosomal region 14q23.1. The protein impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. The protein is also required for normal notochord formation and is downregulated in hepatocellular carcinomas (HCC). It is expressed in human liver and various other tissues.
Specifications

Specifications

DACT1
Polyclonal
Unconjugated
DACT1
Liquid
DACT1, dact1.S
Synthetic peptide (740 DTSEDEQSNYTTNC 753) of Dapper homolog 1 protein.
Protein G
RUO
Antibody
Polyclonal
Chicken, Human, Mouse, Non-human primate, Rat, Xenopus laevis, Zebrafish
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q9NYF0, Q8R4A3, Q6QZN6
DAPPER, DAPPER1, DPR1, FRODO, HDPR1, THYEX3, dapper homolog 1, hepatocellular carcinoma novel gene 3 protein, heptacellular carcinoma novel gene 3
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
398315, 405799, 500666, 51339, 59036, 723789
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