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CD263 (TRAIL-R3) Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1956

Catalog No. PA1956


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Description

Description

PA1-956 detects decoy receptor 1 (DcR1) from human and rat tissues and cells. PA1-956 has been successfully used in FACS and Western blot procedures. By Western blot, this antibody detects an ~30 kDa protein representing DcR1 from HEK293 cell lysate. PA1-956 immunizing peptide corresponds to amino acid residues 24-35 of human DcR1. PA1-956 immunizing peptide (Cat. No. PEP-047) is available for use in neutralization and control experiments.

DcR1 / TRAIL-R3 / TRID / LIT is one of the two putative decoy receptors identified for TRAIL, one of the members of TNF family of apoptosis inducing proteins. The other putative decoy receptor is called DcR2 / TRUNDD / TRAIL-R4. DcR1 is attached to the cell surface through glycophospholipid anchor. It has the extracellular TRAIL binding domain but lacks the cytoplasmic domain to induce apoptotic signal. Hence overexpression of DcR1 inhibits the TRAIL induced apoptosis.
Specifications

Specifications

CD263 (TRAIL-R3)
Polyclonal
Unconjugated
TNFSF10
Liquid
TNFRSF10C, TNFSF10
Synthetic Peptide: Y(24) S A T T A R Q E E V P(35) C
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Flow Cytometry, Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
O14798, P50591
CD263, DCR1, LIT, MGC149501, MGC149502, TRAILR3, TRID
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
246775, 8743, 8794
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