CD263 (TRAIL-R3) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA1956

Catalog No. PA1956

Description

PA1-956 detects decoy receptor 1 (DcR1) from human and rat tissues and cells. PA1-956 has been successfully used in FACS and Western blot procedures. By Western blot, this antibody detects an ∽30 kDa protein representing DcR1 from HEK293 cell lysate. PA1-956 immunizing peptide corresponds to amino acid residues 24-35 of human DcR1. PA1-956 immunizing peptide (Cat. No. PEP-047) is available for use in neutralization and control experiments.

DcR1 / TRAIL-R3 / TRID / LIT is one of the two putative decoy receptors identified for TRAIL, one of the members of TNF family of apoptosis inducing proteins. The other putative decoy receptor is called DcR2 / TRUNDD / TRAIL-R4. DcR1 is attached to the cell surface through glycophospholipid anchor. It has the extracellular TRAIL binding domain but lacks the cytoplasmic domain to induce apoptotic signal. Hence overexpression of DcR1 inhibits the TRAIL induced apoptosis.

Specifications

• Antigen: CD263 (TRAIL-R3)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: O14798, P50591
• Gene Symbols: TNFRSF10C, TNFSF10
• Immunogen: Synthetic Peptide: Y(24) S A T T A R Q E E V P(35) C
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Western Blot
• Concentration: 1 mg/mL
• Gene: TNFSF10
• Gene Alias: CD263, DCR1, LIT, MGC149501, MGC149502, TRAILR3, TRID
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 246775, 8743, 8794
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid