Delta-Like Protein 4 Mouse anti-Human, PE, Clone: MHD4-46, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564412
The MHD4-46 monoclonal antibody specifically binds to Delta-Like Protein 4 which is also known as Delta4, DLL4, and DL4. Delta-Like Protein 4 is a type 1 transmembrane glycoprotein which belongs to the Delta/Serrate/Jagged Family of Notch receptor ligands. The Notch family of transmembrane receptors and their ligands play key roles in various developmental and postnatal processes by controlling cell-fate decisions. Delta-Like Protein 4 is expressed by vascular endothelial cells within certain normal tissues and tumors. It signals through Notch1 and Notch 4 Receptors and plays a critical role in vascular development and homeostasis. Delta-Like Protein 4 expression is upregulated in response to vascular endothelial growth factor (VEGF) and regulates endothelial cell proliferation during vascular sprouting. Delta-Like Protein 4 is also expressed by activated human monocytes and dendritic cells that have been stimulated with proinflammatory activators such as lipopolysaccharide. Recent evidence suggests that Delta-Like Protein 4 may contribute to the T cell potential of CD34+ cells and to the growth of various tumors, and promote tumor cell infiltration.
During product development, the specificity of the purified MHD4-46 antibody (Cat. No. 564589) was confirmed by immunohistochemical staining of acetone-fixed frozen sections of human placenta. Vascular endothelial cells were specifically stained (data not shown).
|Delta-Like Protein 4|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|DLL4; Delta-like 4; DL4; Delta ligand 4; Delta4; Notch ligand DLL4|
|Human Delta-Like Protein 4 Recombinant Protein|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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