Delta-Like Protein 4 Mouse anti-Human, PE, Clone: MHD4-46, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 564412

Catalog No. BDB564412

Description

The MHD4-46 monoclonal antibody specifically binds to Delta-Like Protein 4 which is also known as Delta4, DLL4, and DL4. Delta-Like Protein 4 is a type 1 transmembrane glycoprotein which belongs to the Delta/Serrate/Jagged Family of Notch receptor ligands. The Notch family of transmembrane receptors and their ligands play key roles in various developmental and postnatal processes by controlling cell-fate decisions. Delta-Like Protein 4 is expressed by vascular endothelial cells within certain normal tissues and tumors. It signals through Notch1 and Notch 4 Receptors and plays a critical role in vascular development and homeostasis. Delta-Like Protein 4 expression is upregulated in response to vascular endothelial growth factor (VEGF) and regulates endothelial cell proliferation during vascular sprouting. Delta-Like Protein 4 is also expressed by activated human monocytes and dendritic cells that have been stimulated with proinflammatory activators such as lipopolysaccharide. Recent evidence suggests that Delta-Like Protein 4 may contribute to the T cell potential of CD34+ cells and to the growth of various tumors, and promote tumor cell infiltration.

During product development, the specificity of the purified MHD4-46 antibody (Cat. No. 564589) was confirmed by immunohistochemical staining of acetone-fixed frozen sections of human placenta. Vascular endothelial cells were specifically stained (data not shown).

Specifications

• Antigen: Delta-Like Protein 4
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: DLL4; Delta-like 4; DL4; Delta ligand 4; Delta4; Notch ligand DLL4
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: MHD4-46
• Conjugate: PE
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Human Delta-Like Protein 4 Recombinant Protein
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.