MilliporeSigma™ anti-deltaNp73 Clone: 38C674,

Catalog No.	Quantity	Conjugate
OP181100UG	100 μg	Unconjugated

Catalog No. OP181100UG Supplier MilliporeSigma™ Supplier No. OP181100UG

Description

Mouse Monoclonal Antibody

Specifically detects ΔNp73 Clone: 38C674 in Human samples, and it is validated for Immuno Blotting

p73 is a relative of tumor suppressor protein p53. It displays a high homology with p53 and with p63, a gene implicated in the maintenance of epithelial stem cells. Significant homology between p53, p63, and p73 suggests that they may have overlapping functions involved in the regulation of gene expression. The disruption of p73 leads to hippocampal dysgenesis, hydrocephalus, chronic inflammation, and infections. Splicing variant mRNAs of p73 have been identified in MCF7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxyl-terminal structures, suggesting that this region of p73 may be important for the functions of this protein. Researchers have recently cloned a p73 variant that lacks an amino-terminal transactivation domain, called ΔNp73. The ΔNp73 message is transcribed from an alternative promoter located in intron 3.

Specifications

• Antigen: ΔNp73
• Applications: Immunoblot
• Classification: Monoclonal
• Clone: 38C674
• Conjugate: Unconjugated
• Formulation: In PBS, 0.2% gelatin.
• Host Species: Mouse
• Immunogen: a synthetic peptide (LYVGDPARHLAT) corresponding to amino acids 2-13 of human ΔNp73
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽73kDa ΔNp73 protein.
• Target Species: Human
• Content And Storage: −20°C
• Form: Purified
• Isotype: IgG1

For Research Use Only