Dendritic Cells Rat anti-Mouse, BB515, Clone: 33D1, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 565171
The 33D1 antibody recognizes Dendritic cell inhibitory receptor 2 (Dcir2) which is also known as, Dendritic Cells antigen, Dendritic Cell (DC) Marker, or 33D1 antigen. This antigen is expressed on most dendritic cells of spleen, lymph node, and Peyer's patch, but not liver, bone marrow, or epidermal dendritic cells; macrophages; other leukocytes; or erythroid cells. Within the spleen, the majority of 33D1+ DC are localized in the marginal zones. Thymic dendritic cells may express a low level of the 33D1 Antigen. It has been reported that bone-marrow DC can be induced to express the 33D1 antigen by culture in the presence of GM-CSF, and the resulting 33D1+ DC are effective in in vitro (induction of MLR) and in vivo (anti-tumoral vaccination) assays for antigen presentation. However, the addition of IL-4 to GM-CSF in bone-marrow cultures resulted in loss of 33D1 expression and enhanced the MLR-stimulatory activity of the DC. It has also been reported that 33D1 expression is upregulated when liver-derived DC are cultured on collagen-coated plates in the presence of GM-CSF. In vivo functional 33D1+ DC are induced in the brains of mice chronically infected with Toxoplasma gondii , probably via the parasite's induction of GM-CSF.
|Aqueous buffered solution containing ≤0.09% sodium azide|
|Dcir2; Dendritic Cell Marker; DC Marker; Dendritic Cells Ag; 33D1 Antigen|
|Dendritic cells purified from mouse spleen and lymph node|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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