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Desmoglein Mouse, Unlabeled, Clone: 62, BD

Catalog No. BDB610274 Shop All BD Biosciences Products
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BDB610274 150 μg
BDB610273 50 μg
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Catalog No. BDB610274 Supplier BD Biosciences Supplier No. 610274

Description

Mouse Monoclonal Antibody

Desmoglein (Dsg1) is a transmembrane glycoprotein found in desmosome junctions. Desmosomes and adherens junctions are plasma membrane specializations involved in cell-cell adhesion. They serve as membrane anchorage domains for intermediate filaments and microfilaments, respectively. Actin microfilaments anchor at adherens junctions, which occur in many sizes, shapes, and positions. These junctions generally contain E- or N-Cadherin whose cytoplasmic region is associated with cytoplasmic proteins such as α- and β- catenin, vinculin, α-actinin, and radixin. Intermediate filaments (IFs) are anchored at desmosomes which contain desmosome-specific cadherin family members, known as desmocollin (Dsc) and desmoglein. These proteins associate with cytoplasmic proteins such as desmoplakin and plakoglobin (γ-Catenin). Plakoglobin is the only junctional protein found at both desmosomes and adherens junctions and, therefore, plays a crucial role in cell adhesion.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Desmoglein
Applications Western Blot
Classification Monoclonal
Clone 62
Concentration 250μg/mL
Conjugate Unconjugated
Description Dsg1
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Chicken, Drosophila, Human, Mouse, Rat
Isotype IgG2b
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For Research Use Only.

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