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DISC1 Rabbit anti-Human, Mouse, Rat, DyLight® 650, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522837

Catalog No. PIPA522837


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Description

Description

The theoretical molecular weight of DISC1 is ~90 kDa. Due to alternative splicing, DISC1 may also run at ~75 and 100 kDa. Suggested positive control: human brain sections (neurons and glia).

DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system, and is involved in neuronal functions that are dependent upon proper cytoskeletal regulation, including neuronal migration, neurite architecture and intracellular transport. Regions of the brain which express DISC1 include the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum and paraventricular hypothalamus, and loss of DISC1 function results in differences in structural organization. The DISC1 gene locus is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2, beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.
Specifications

Specifications

DISC1
Polyclonal
DyLight® 650
DISC1
Liquid
DISC1
A synthetic peptide made to an internal region (within residues 400-500) of the rat DISC1 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
0.85 mg/mL
sodium borate with no preservative
Q9NRI5, Q811T9, Q810H6
RP4-730B13.1, C1orf136, SCZD9, disrupted in schizophrenia 1 protein
Rabbit
IgG
100 μL
4° C, store in dark
Primary
244667, 27185, 307940
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