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Disialoganglioside GD2 Mouse anti-Human, Alexa Fluor 647, Clone: 14.G2a, BD

Catalog No. BDB562096 Shop All BD Biosciences Products
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BDB562096 50 Tests
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Catalog No. BDB562096 Supplier BD Biosciences Supplier No. 562096
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Description

Mouse Monoclonal Antibody

Gangliosides are sialic-acid bearing glycolipids that are expressed on the surface of all mammalian cells, and are likely involved in mediating cell-substratum interactions. They are important target antigens for antibody dependent cellular cytotoxicity (ADCC) of human melanoma and neuroblastoma cells. Human melanoma cells produce gangliosides, designated as GD2 and GD3 which are deposited in the subtratum-attached material, and may play a significant role in the melanoma metastatic phenotype. Clone 14.G2a specifically reacts with human and mouse GD2 ganglioside. LAN-1 human neuroblastoma cells were used as immunogen. Clone 14.G2a is an isotype switch variant selected from the parental IgG3-producing hybridoma 14.18 and has identical reactivity as the parental antibody. Clone 14.G2a is routinely tested by flow cytometry using M21 human melanoma cells.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Disialoganglioside GD2
Applications Flow Cytometry
Classification Monoclonal
Clone 14.G2a
Conjugate Alexa Fluor 647
Formulation Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen LAN-1 human neuroblastoma cells
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a
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