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DLAT Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525260

Catalog No. PIPA525260


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Description

Description

DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure.
Specifications

Specifications

DLAT
Polyclonal
PBS with 0.09% sodium azide
P10515
DLTA, PDC-E2, PDCE2, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, E2 component of pyruvate dehydrogenase complex, M2 antigen complex 70 kDa subunit, PBC, dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, dihydrolipoyllysine-residue a
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1737
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
DLAT
Liquid
DLAT
KLH conjugated synthetic peptide between 579-607 amino acids from the C-terminal region of human DLAT
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Documents
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