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DMPK, Mouse, Clone: 2F7, Abnova™

Catalog No. 89021334 Shop All Abnova Corporation Products
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100 μg
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Catalog No. Quantity
89-021-334 100 μg
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Catalog No. 89-021-334 Supplier Abnova Corporation Supplier No. H00001760M01
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Description

Mouse monoclonal antibody raised against a partial recombinant DMPK.

The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq]

Sequence: DEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTP

Specifications

Antigen DMPK
Applications ELISA, KnockDown, Western Blot
Classification Monoclonal
Clone 2F7
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against a partial recombinant DMPK.
Formulation PBS with no preservative; pH 7.4
Gene DMPK
Gene Accession No. BC062553
Gene Alias DM/DM1/DM1PK/DMK/MDPK/MT-PK
Gene Symbols DMPK
Host Species Mouse
Immunogen DMPK (AAH62553, 303 a.a. ∼ 420 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1760
Target Species Human
Content And Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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