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Description
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq]
Specifications
Specifications
| Antigen | DNTT |
| Applications | ELISA, Western Blot |
| Classification | Monoclonal |
| Clone | 4H5 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against a partial recombinant DNTT. |
| Formulation | PBS with no preservative; pH 7.4 |
| Gene | DNTT |
| Gene Accession No. | BC012920 |
| Gene Alias | TDT |
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