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Doublecortin Mouse anti-Mouse, Unlabeled, Clone: 30, BD

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BDB611706 50 μg
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Catalog No. BDB611706 Supplier BD Biosciences Supplier No. 611706

Description

Mouse Monoclonal Antibody

The cerebral cortex is composed of multiple layers of neurons of distinct types and functions, which perform in unison to orchestrate cognitive function. The formation of the cortex relies on complex signaling mechanisms, which mediate the migration of newly formed neurons from deep within the brain to the superficial regions. Defects in neuronal migration and disruption of the multi-layered cortex are apparent in conditions such as X-linked lissencephaly (XLIS) and subcortical laminar heterotopia (SCLH) or “double cortex” (DC) syndrome. Mutations in the doublecortin gene have been linked to these brain disorders. Doublecortin is highly expressed in developing brain, primarily in migrating neurons. It is significantly homologous with the N-terminal region of the product of the KIAA0369 gene, a protein that is also similar to the CaM kinase family in its C-terminal region. Doublecortin has four potential MAP kinase family phosphorylation sites and a putative site for Abl tyrosine phosphorylation. Thus, doublecortin is thought to be an integral component of tyrosine kinase signal transduction pathways that regulate neuronal migration and development of the cerebral cortex.

Host Species: Mouse
Clone: 30
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse Doublecortin aa. 211-317

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Doublecortin
Applications Western Blot
Classification Monoclonal
Clone 30
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse Doublecortin aa. 211-317 Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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