DR1-associated protein 1 (negative cofactor 2 alpha), Mouse, Polyclonal Antibody, Abnova
Mouse polyclonal antibody raised against a partial recombinant DRAP1.
Manufacturer: Abnova Corporation H00010589A01
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeqSequence: PSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHMDGD
|DR1-associated protein 1 (negative cofactor 2 alpha)|
|ELISA, Western Blot|
|Mouse polyclonal antibody raised against a partial recombinant DRAP1.|
|DRAP1 (NP_006433, 2 a.a. ~ 105 a.a) partial recombinant protein with GST tag.|
|Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
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