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DSIF Mouse, Unlabeled, Clone: 17, BD

Mouse Monoclonal Antibody

$225.00 - $419.00

Specifications

Antigen DSIF
Isotype IgG1
Immunogen Human DSIF aa. 866-985
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611107
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BD Biosciences
611107
150μg Each for $419.00
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BDB611106
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BD Biosciences
611106
50μg Each for $225.00
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Description

Description

In living systems, the relative amounts of any protein are controlled at many levels. For example, amounts are affected by protein degradation, regulation of the translational rates of polypeptide synthesis (translational regulation), and control of the rates of mRNA synthesis (transcriptional regulation). Transcriptional regulation involves modulation of the rate-limiting enzyme RNA polymerase. DSIF (DRB sensitivity-inducing factor) is a heterodimeric transcription elongation protein. It is composed of a large subunit of 160kDa and a small subunit of 14kDa. These large and the small subunits are homologs of the yeast gene products Stp5 and Stp4, respectively. Spt4 and 5 are transcription factors which are critically important for the activity of RNA polymerase. In conjunction with DRB, DSIF attenuates RNA polymerase II elongation steps. However, in limiting amounts of ribonucleotides, DSIF, by itself, stimulates the elongation rate of RNA polymerase II. Thus, the identification of a human regulator for transcriptional elongation will greatly enhance our understanding of this critical step in mammalian gene expression.

Host Species: Mouse
Clone: 17
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human DSIF aa. 866-985
Formula Weight [Chemical]: 160kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

DSIF
Human DSIF aa. 866-985
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
17
250μg/mL

For Research Use Only.

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