DUSP14 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA515565
This antibody is predicted to react with bovine based on sequence homology.DUSP14 is involved in the inactivation of MAP kinases. This protein dephosphorylates ERK, JNK and p38 MAP-kinases. In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28, which interacts with B7-1 and B7-2 ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK and JNK, and the subsequent creation of AP1 transcription factor. DUSP14 is a negative regulator of CD28 signaling.
|PBS with 0.09% sodium azide|
|Mitogen-activated protein kinase phosphatase 6; MAP kinase phosphatase 6; MKP-6; MKP-1-like protein tyrosine phosphatase; MKP-L;|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DUSP14|
|Ammonium sulfate precipitation, Size-exclusion - Dialysis|
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