DUSP3, Mouse, Clone: 5B7, Abnova™

Mouse monoclonal antibody raised against a full-length recombinant DUSP3.

Manufacturer: Abnova Corporation H00001845M01

Catalog No. 89-021-368

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    Specifications

    Antigen DUSP3
    Applications Enzyme Linked Immunosorbent Assay,Western Blotting
    Clone 5B7
    Conjugate Unlabeled
    Cross Reactivity Human
    Description dual specificity phosphatase 3
    Format Liquid
    Formulation In 1X PBS, pH 7.4
    Gene DUSP3
    Gene Accession No. BC002682
    Gene Alias VHR
    Gene Symbols DUSP3
    Host Species Mouse
    Immunogen DUSP3 (AAH02682, 1 a.a. ∽186 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26kDa
    Isotype IgG2a, κ
    Quantity 50μg
    Regulatory Status RUO
    Species Reactivity Human
    Storage Requirements Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
    Primary or Secondary Primary
    Monoclonal or Polyclonal Monoclonal
    Gene ID (Entrez) 1845

    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq

    Sequence: MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP

  • Description & Specifications

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